Frontiers | Restraint Stress-Induced Morphological Changes at the Blood-Brain Barrier in Adult Rats | Frontiers in Molecular Neuroscience

Most stress episodes provoke a controlled response of the organism, which is essential for survival and may enhance performance. Intense or prolonged exposure to stress, in contrast, may lead to a variety of neuropsychiatric disorders (Chrousos, 2009). Stressful stimuli are reported to impair synaptic plasticity in the hippocampus and to inhibit hippocampal neurogenesis (Kim et al., 2013; Maggio et al., 2013; Schoenfeld and Gould, 2013; Grigoryan et al., 2014). Furthermore, retrospective epidemiological studies indicate that stress is associated with increased risk of dementia and development of neurological or psychiatric disorders, such as Alzheimer’s disease or major depressive disorder (Wilson et al., 2006, 2007; Najjar et al., 2013).

Source: Frontiers | Restraint Stress-Induced Morphological Changes at the Blood-Brain Barrier in Adult Rats | Frontiers in Molecular Neuroscience

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